Aromadendrin (Dihydroflavonol · Anti-inflammatory · Antimicrobial)
| Compound | Aromadendrin (Dihydrokaempferol; 3,5,7,4′-Tetrahydroxyflavanone) |
| Chemical class | Polyphenol — Flavanonol (Dihydroflavonol; C2-C3 saturated kaempferol) |
| CAS | 480-20-6 |
| Primary source | Pinus spp. (pine bark), Vitis vinifera (grape), Eucalyptus spp., Rhododendron spp. |
| Key applications | Anti-inflammatory; antimicrobial; antioxidant; vascular tone support |
| Claim strength | Moderate |
| Typical form | Pine Bark Extract Powder; Grape Seed Extract Powder 95% OPC; as minor flavanonol in OPC matrices |
| Buy from Herbuno |
Pine Bark Extract Powder → Grape Seed Extract Powder 95% - Vitis vinifera → |
Name origin: Aromadendrin was first isolated from Eucalyptus aromadendron — the species name providing the compound name. It is also known as dihydrokaempferol, denoting its structural relationship to kaempferol: the C2–C3 double bond of kaempferol is saturated in aromadendrin, placing it in the flavanonol (dihydroflavonol) sub-class alongside taxifolin (dihydroquercetin). Traditional use: Pine bark preparations have been used in French maritime tradition and North American indigenous medicine for circulatory support and wound healing. Pycnogenol (French maritime pine bark extract) is the most clinically researched preparation and contains aromadendrin alongside taxifolin, catechins, and phenolic acids. Research trajectory: Aromadendrin occupies an intermediate position in flavonoid biosynthesis — a direct precursor to kaempferol and naringenin in plant secondary metabolism. Research has characterised anti-inflammatory, antimicrobial, and vascular-tone activities. Commercial source: Aromadendrin is available from Herbuno via Pine Bark Extract Powder and Grape Seed Extract Powder 95% OPC, both well-established extract categories in the vascular and antioxidant supplement market.
Evidence for Aromadendrin Applications
Anti-inflammatory activity: Aromadendrin inhibits COX-1 and COX-2 activity and suppresses NF-κB in macrophage activation models. Compared to taxifolin, aromadendrin's B-ring lacks the 3′-hydroxyl, reducing catechol-dependent radical scavenging but maintaining COX inhibition capacity. Claim strength: Moderate.
Antimicrobial activity: Aromadendrin demonstrates MIC values of 50–200 μg/mL against Staphylococcus aureus (including MRSA), Streptococcus mutans, and Candida albicans in disc diffusion and broth dilution assays. Activity relates to membrane permeability disruption and efflux pump inhibition. No clinical antimicrobial data are available. Claim strength: Emerging.
Vascular and antioxidant: In the context of Pycnogenol preparations — which contain aromadendrin as a constituent — multiple RCTs demonstrate benefits in chronic venous insufficiency, leg oedema, and endothelial function. Isolated aromadendrin vascular data are extrapolated from pine bark extract research. Claim strength: Moderate (extract); Emerging (isolated).
Biosynthetic pathway interest: Aromadendrin (dihydrokaempferol) is the branch point for kaempferol, naringenin, and leucoanthocyanidins in plant biosynthesis — relevant for biotechnological flavonoid production research. Claim strength: Emerging.
Pine Bark Extract Powder →
Grape Seed Extract Powder 95% - Vitis vinifera →
Browse Standardised Extract Powders →
Dosage & Formulator Specification
No isolated aromadendrin clinical dosing data exist. Pine bark extract (Pycnogenol) is studied at 50–300 mg/day in cardiovascular and inflammatory applications; Vitis vinifera grape seed extract OPC preparations at 100–300 mg/day. Aromadendrin is a minor constituent of these extracts — standardisation to total OPC (≥95%) or proanthocyanidins is more common than individual flavanonol specification.
Both pine bark and grape seed extracts are compatible with solid dosage (capsule, tablet), liquid, and functional food formats. Grape seed extract at OPC 95% is water-soluble; pine bark extract has moderate water solubility and benefits from microencapsulation in beverage applications. Stability at pH 3–6 is good for both.
No significant drug interactions are documented for aromadendrin in isolation. Pine bark extract has mild antiplatelet activity; note for anticoagulant co-medication contexts.
Combining pine bark extract (aromadendrin-containing) with Siberian larch-derived taxifolin creates a complementary flavanonol matrix with overlapping but distinct antioxidant and anti-inflammatory mechanisms.
Frequently Asked Questions — Aromadendrin
What is the difference between aromadendrin and taxifolin?
Both are flavanonols: taxifolin is dihydroquercetin (3′,4′-dihydroxy B-ring) while aromadendrin is dihydrokaempferol (4′-monohydroxy B-ring). Taxifolin's additional 3′-hydroxyl gives stronger radical scavenging and iron chelation; aromadendrin has cleaner COX inhibition data and broader antimicrobial activity.
Is aromadendrin standardised in commercial pine bark extracts?
Not typically at compound-specific level. Commercial pine bark extracts are standardised to total OPC or total polyphenol content, with aromadendrin present as a minor flavanonol constituent. Individual aromadendrin quantification is available by HPLC on request.
Which Herbuno products contain aromadendrin as a significant constituent?
Pine Bark Extract Powder and Grape Seed Extract Powder 95% OPC both contain aromadendrin as part of the polyphenol complex. Black Grapes Powder is a third relevant source with lower concentrations.
Can aromadendrin be combined with taxifolin in vascular formulations?
Yes — combining pine bark extract (aromadendrin-containing) with Siberian larch-derived taxifolin creates a complementary flavanonol matrix. Both are well-tolerated and compatible with OPC extracts and vitamin C.
Related compounds: Taxifolin, Kaempferol, Patuletin, Laricitrin
Claim-strength scale – High = multiple human RCTs; Moderate = limited trials or strong preclinical convergence; Emerging = early-stage lab or animal data.
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