Diosmin (Flavone Glycoside · Phlebotonic · Venous Insufficiency)
| CAS No. | 520-27-4 |
| Class | Polyphenol · Flavone Glycoside · Flavonoid |
| Source | Citrus sinensis / Citrus aurantium peel; commercial production via semi-synthetic hesperidin oxidation |
| Claim strength | High |
| Buy from Herbuno | Diosmin 10% (From Citrus) powder → · Diosmin 95% Powder (Citrus-Derived) | High-Purity Flavone Glycoside | Citrus aurantium → |
Origin and commercial production: Diosmin is a flavone glycoside — diosmetin-7-O-rutinoside — found naturally in citrus peel but commercially manufactured by semi-synthetic oxidation of hesperidin, converting the flavanone to a flavone structure. Pharmaceutical landmark: The combination product Daflon (90% diosmin + 10% hesperidin, micronised) is one of the most studied phlebotonic agents in clinical medicine and is licensed as a pharmaceutical in over 30 countries. Evidence depth: More than 13 RCTs and a Cochrane-level systematic review support its use for chronic venous disease — an unusually strong evidence base for a botanical ingredient. Market position: Diosmin is the most commercially established single phlebotonic flavone globally, available in both pharmaceutical-grade micronised form and standard supplement-grade extract powder.
Evidence for Venous Insufficiency, Haemorrhoids & Lymphoedema
Chronic venous insufficiency: The Daflon evidence base (13+ RCTs, Cochrane-level review) documents significant reductions in venous symptoms (heaviness, aching, night cramps, swelling), improved venous haemodynamics, and acceleration of venous ulcer healing at 1,000 mg/day diosmin fraction. Licensed as a pharmaceutical in France, Brazil, Portugal, and many other markets. Claim strength: High.
Haemorrhoids: Multiple RCTs show diosmin 1,000 mg/day significantly reduces duration, severity, and bleeding of acute haemorrhoidal attacks and reduces recurrence frequency with maintenance dosing. Effect sizes are clinically meaningful. Claim strength: High.
Lymphoedema: Documented lymphotonicity — increasing lymphatic vessel contractility and lymph flow — with clinical evidence for reductions in limb circumference in lymphoedema patients. Claim strength: Moderate.
Microcirculation: Reduces capillary permeability, inhibits prostaglandin synthesis in venous walls, and reduces neutrophil adhesion to venous endothelium. Claim strength: High.
Diosmin 10% (From Citrus) powder →
Diosmin 95% Powder (Citrus-Derived) | High-Purity Flavone Glycoside | Citrus aurantium →
Browse Standardised Extract Powders →
Dosage, Micronisation & Formulator Specification
Clinical dose: 500 mg twice daily (1,000 mg/day) is the standard in clinical trials and pharmaceutical preparations. Acute haemorrhoidal attack: 500 mg three times daily for 4 days, then 500 mg twice daily for 3 days. Maintenance: 500–1,000 mg/day.
Micronised vs standard grade: The pharmaceutical Daflon product uses micronised diosmin (particle size <2 μm) to significantly improve dissolution and absorption vs standard powder. For formulations aiming to match pharmaceutical bioavailability, micronised diosmin is the appropriate specification. Confirm particle size specification when ordering.
Semi-synthetic origin: Commercial diosmin is predominantly semi-synthetic from citrus hesperidin — standard practice that does not affect safety or regulatory status. For strictly natural extraction grades, confirm with the supplier as they command a premium.
Synergistic pairs: Hesperidin (the clinical combination; 9:1 diosmin:hesperidin = Daflon standard), rutin (capillary support combination), vitamin C (connective tissue and capillary wall integrity), escin/horse chestnut (complementary venous tonic).
Frequently Asked Questions — Diosmin
Is diosmin the same as Daflon?
Daflon is a combination product containing 90% diosmin and 10% hesperidin in micronised form. The pharmaceutical evidence base is for this combination in micronised form — not isolated diosmin alone. When formulating for venous applications, the convention is to combine diosmin with hesperidin at a 9:1 ratio.
Can diosmin be used during pregnancy for haemorrhoids?
The diosmin-hesperidin combination has been used clinically for gestational haemorrhoids and appears in some European guidelines as an option in the second and third trimesters. Standard precautionary labelling for pregnancy and breastfeeding applies in regulated supplement markets. Pregnant women should consult their healthcare provider.
What is the difference between diosmin and diosmetin?
Diosmetin is the aglycone form (no sugar). Diosmin is diosmetin-7-O-rutinoside (the glycoside). Commercial products use diosmin because it is manufactured in large quantities from citrus hesperidin with established pharmaceutical precedent.
How does diosmin compare to horse chestnut for venous insufficiency?
Both are well-evidenced phlebotonic ingredients with complementary mechanisms. Diosmin acts on venous tone, capillary permeability, and lymph flow. Horse chestnut (escin) inhibits lysosomal enzymes degrading capillary basement membranes. The two are mechanistically complementary and can be rationally combined in a comprehensive venous support formula.
Claim-strength scale – High = multiple human RCTs; Moderate = limited trials or strong preclinical convergence; Emerging = early-stage lab or animal data.
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