Speciociliatine (Kratom Indole Alkaloid · Mitragynine Diastereomer · Informational)
Compiled from published pharmacological and botanical literature. Not independently verified by Herbuno. Spotted an error or have a correction? Flag it below →
| Compound | Speciociliatine |
| Chemical class | Alkaloid — Indole (corynanthe-type; C-3 diastereomer of mitragynine) |
| CAS | 16413-68-0 |
| Primary source | Mitragyna speciosa (kratom), leaves |
| Key applications | Minor kratom alkaloid; opioid-related research context; controlled/variable status; informational-only |
| Claim strength | Emerging (research); controlled/variable status |
| Typical form | Research reference; not offered as a supplement ingredient |
| Buy from Herbuno | Informational reference — see HerbIQ Compound Index → |
Name origin: Speciociliatine takes its name from Mitragyna speciosa and is a corynanthe-type indole alkaloid, specifically a C-3 diastereomer of mitragynine — that is, the same connectivity as mitragynine but a different spatial configuration at one stereocentre. Traditional use: As a minor kratom leaf constituent, speciociliatine has no distinct traditional identity separate from kratom itself, whose leaves are traditionally chewed or brewed in Southeast Asia; it is delivered incidentally as one of the many minor alkaloids accompanying mitragynine in whole leaf. Research trajectory: Speciociliatine is one of the naturally occurring diastereomers of mitragynine, and a review of the chemical and pharmacological properties of mitragynine and its diastereomers characterises this group’s shared indole scaffold together with their differing receptor interactions and potencies Chittrakarn 2022. Its individual pharmacology is less fully defined than that of mitragynine or 7-hydroxymitragynine, and it is generally studied as part of the wider kratom alkaloid family rather than in isolation. Safety and legal context: As a kratom alkaloid with opioid-related activity and variable controlled status, speciociliatine is documented here as a factual research reference only, and is explicitly not a sourcing offer.
Evidence for Speciociliatine Applications
Mitragynine diastereomer: Speciociliatine is a C-3 diastereomer of mitragynine, and the diastereomer group shares the corynanthe indole scaffold while differing in stereochemistry and, as a result, in receptor activity, as characterised in a dedicated review of mitragynine and its diastereomers Chittrakarn 2022. Understanding these stereochemical differences is part of mapping the structure-activity relationships of the kratom alkaloids. Claim strength: Emerging.
Opioid-related activity: Like other kratom alkaloids, speciociliatine interacts with opioid receptors, though with a profile distinct from that of mitragynine, and the specifics of its potency and selectivity remain an area of active characterisation rather than settled knowledge Chittrakarn 2022. Claim strength: Emerging.
Minor constituent: Speciociliatine occurs as a minor alkaloid of kratom leaf, contributing to the plant’s complex alkaloid mixture rather than dominating its effects, so its practical relevance is largely as one component of the whole-leaf alkaloid profile Chittrakarn 2022. Claim strength: Emerging.
Structure-activity context: Because it differs from mitragynine only in configuration at one centre, speciociliatine is a useful comparison point for understanding how stereochemistry modulates activity across the corynanthe kratom alkaloids — a recurring theme in the medicinal chemistry of this family Chittrakarn 2022. Claim strength: Emerging.
Analytical relevance: Speciociliatine is one of the alkaloids resolved when kratom material is profiled by chromatographic methods, and its presence and proportion form part of the detailed alkaloid fingerprint used to characterise leaf material in research. Claim strength: Emerging.
Position within the alkaloid family: As a naturally occurring diastereomer rather than a metabolite or a synthetic derivative, speciociliatine is present in the leaf itself, and its ratio to mitragynine is one of the compositional features that can distinguish kratom material of different origins; this gives it modest value as an authenticity and provenance marker alongside its role in structure-activity research. Claim strength: Emerging.
This compound is documented for research and formulator education purposes. For commercially available botanical ingredients, explore the HerbIQ Compound Index →
Dosage & Formulator Specification
Speciociliatine is documented here for research and formulator education only; Herbuno does not offer it as an ingredient. As a kratom alkaloid with opioid-related activity and controlled or variable legal status, it is not appropriate for supplement formulation, and no consumer dosing is provided.
Its content in kratom leaf is minor and variable, and its individual pharmacology is incompletely defined, so it is best understood as one component of the whole-leaf alkaloid profile rather than a target of isolation. There is no supplement-grade application, and formulators must treat all kratom alkaloids as regulated substances whose status must be verified per market before any handling.
From an analytical standpoint, speciociliatine appears as one peak in the chromatographic alkaloid fingerprint of kratom material, and its measurement is useful chiefly for characterising and authenticating leaf rather than for any product purpose. This analytical role sits within the same LC-MS profiling used to quantify mitragynine and 7-hydroxymitragynine, and it reinforces that the meaningful unit of assessment for kratom is the full alkaloid profile.
Speciociliatine illustrates a broader point about the kratom alkaloids that is easy to miss: the plant produces not one or two but dozens of structurally related compounds, and the overall effect of any leaf material reflects the whole ensemble rather than any single alkaloid. The diastereomers in particular show how small stereochemical differences ripple through to receptor pharmacology, which is why serious characterisation of kratom material depends on full alkaloid profiling rather than on a single headline number, and why minor alkaloids like speciociliatine are worth documenting individually.
This page provides factual chemical and pharmacological context within the HerbIQ index, situating speciociliatine alongside mitragynine and 7-hydroxymitragynine, and is not sourcing guidance.
Frequently Asked Questions — Speciociliatine
What is speciociliatine?
Speciociliatine is a minor indole alkaloid of Mitragyna speciosa (kratom), a diastereomer of mitragynine differing in stereochemistry at the C-3 position. It shares the corynanthe indole scaffold of the main kratom alkaloids but occurs as a minor constituent.
How does speciociliatine relate to mitragynine?
Speciociliatine is one of mitragynine’s naturally occurring diastereomers; the kratom diastereomers share the corynanthe indole scaffold but differ in stereochemistry and, consequently, in receptor activity and potency. Speciociliatine is generally a minor leaf alkaloid rather than a dominant one.
Why is speciociliatine informational-only?
As a kratom alkaloid with opioid-related activity and variable controlled status, it is documented for research and education only and is not offered as an ingredient by Herbuno.
Is speciociliatine well studied?
Less so than mitragynine or 7-hydroxymitragynine. It is characterised mainly within reviews of mitragynine and its diastereomers, and its individual pharmacology is still being defined; it is best understood as one member of the broader kratom alkaloid family.
Related compounds: Mitragynine, 7-Hydroxymitragynine, Ibogaine, Yohimbine
Claim-strength scale – High = multiple human RCTs; Moderate = limited trials or strong preclinical convergence; Emerging = early-stage lab or animal data.
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