Pyridoxal-5-Phosphate (P5P) Powder

Nerve-Calm Capsule: Pack 50 mg with magnesium glycinate for relaxed evenings.

Nootropic Latte: Whisk 50 mg into matcha-oat foam for focus without jitters.

Protein Smoothie: Blend 50 mg with whey & creatine to support amino acid metabolism.

Hormone-Balance Shot: Stir 50 mg into lemon water to aid estrogen detox pathways.

Pre-Workout Stack: Combine 25 mg with 3 g beta-alanine for carnosine synthesis.

Travel Gummies: Disperse 0.05 % in berry chews to curb jet-lag brain fog.

Ready-to-Use B-6: No conversion loss—P-5-P is the bio-active coenzyme form.

Neurotransmitter Support: Required cofactor for serotonin, GABA & dopamine synthesis.

Homocysteine Control: Works with B-9/B-12 to keep cardiovascular markers in range.

Hormone Harmony: Assists liver Phase-II conjugation of estrogen metabolites.

Energy Metabolism: Catalyzes glycogen breakdown for steady workout fuel.

PMS & Mood: Clinically shown to ease bloating, cravings and cyclical irritability.

Serving Size: 1 micro-scoop (≈ 50 mg powder, providing ≈ 49.5 mg P-5-P)

Ingredients: 100 % Pyridoxal-5-Phosphate Powder (≥ 99 % purity)

Allergen Information: Soy-free • Gluten-free • Dairy-free • Non-GMO

Free from: Added sugar • Caffeine • Artificial colours or preservatives

Usage Tip: Combine with 400 µg methyl-folate and 500 µg methyl-B-12 for full methylation and homocysteine support.

Storage: Keep sealed, cool, dry & dark. Reseal tightly after each use.

Keep Away From Children

Q: How much P-5-P should I actually take, and how soon will I notice a difference?

A: Research doses span 25–100 mg daily. Most users start with a single 50 mg scoop at breakfast. Because P-5-P bypasses liver activation, blood levels rise within 30 minutes—some notice calmer nerves and steadier focus the very first day. Homocysteine and PMS improvements show up on lab work or symptom trackers after 4–6 weeks of consistent dosing. If you already supplement methyl-folate and B-12, 50 mg P-5-P usually completes the methylation puzzle without overshooting safe intake.

Q: How does P-5-P differ from ordinary vitamin B-6 (pyridoxine HCl) on a practical level?

A: Pyridoxine HCl must be phosphorylated in the liver and then oxidised to P-5-P before it can enter enzyme binding sites; up to 30 % can be lost in the process, and high doses of pyridoxine may compete with P-5-P transporters, paradoxically lowering active levels. Pure P-5-P sidesteps conversion bottlenecks, so a 50 mg serving can match or exceed the biological effect of 100–150 mg pyridoxine—especially important for people with liver stress, genetic PLP-binding issues or chronic inflammation.

Q: Any interactions with medications such as levodopa, anticonvulsants or oral contraceptives?

A: P-5-P can increase peripheral decarboxylation of levodopa—Parkinson’s patients should only use B-6 under neurologist guidance when not on carbidopa. Anticonvulsants like phenobarbital may lower B-6 status; supplementing 25–50 mg P-5-P often restores plasma PLP without altering drug levels. Oral contraceptives raise B-6 requirements due to estrogen metabolism—many clinicians recommend 25 mg P-5-P to prevent mood dip and homocysteine rise in OC users. Always log supplements for your prescriber.

Q: Does P-5-P have side-effects or a toxicity ceiling?

A: Neuropathy reports tied to vitamin B-6 involve large chronic intakes of pyridoxine (>500 mg/day), not P-5-P. Controlled trials with 100 mg P-5-P daily for 6 months show no sensory issues and stable liver enzymes. Keep daily intake ≤100 mg unless a practitioner supervises higher therapeutic use. Mild nausea can occur if taken on an empty stomach; pairing with food fixes it.